speech-language disorder 1; specific language impairment; developmental verbal dyspraxia (SPCH1)

Genetics

• autosomal dominant
• associated with mutation in gene for forkhead box protein P2

Clinical manifestations

• failure to develop language normally in the absence of hearing impairment of neurological disorder
• severe speech disorder & language disorder
• severe impairment in the selection & sequencing of fine orofacial movements necessary for articulation
• deficits in several facets of language processing, including ability to break up words into their constituent phonemes
• selective impairment in grammar

More general terms

• speech-language disorder

Additional terms

• forkhead box protein P2; CAG repeat protein 44; trinucleotide repeat-containing gene 10 protein (FOXP2)

Database

• OMIM: https://mirror.omim.org/entry/602081