testosterone & risk of depression
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Introduction
Veterans Administration study:
Clinical significance
- low baseline total serum testosterone (< 200 ng/dL) associated with increased risk of depression (22% vs 7%) during 2 years of followup
- testosterone replacement therapy improves mood[2]
Methods
- examination of computerized medical records
References
- ↑ Journal Watch 24(6):48, 2004
Shores MM et al Increased incidence of diagnosed depressive illness in hypogonadal older men. Arch Gen Psychiatry 61:162, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14757592 - ↑ 2.0 2.1 Bhasin S et al. Depressive syndromes in men with hypogonadism in the TRAVERSE trial: Response to testosterone-replacement therapy. J Clin Endocrinol Metab 2024 Jan 11; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38205962 https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae026/7516050