autosomal dominant nonsyndromic sensorineural deafness 28

Genetics

• autosomal dominant
• associated with mutations in GRHL2 gene

Clinical manifestations

• mild to moderate hearing loss across most frequencies
• progresses to severe loss in the higher frequencies by the 5th decade of life
• age at onset variable, with earliest case documented at 7 years of age

More general terms

• familial deafness

Database

• OMIM: https://mirror.omim.org/entry/608641