cyanide poisoning
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Epidemiology
- common in victims of house fires
- 35% of rescued victims have signifcantly elevated cyanide in serum/plasma
Pathology
- cyanide interferes with mitochondrial respiration
- cyanide binds strongly to heme
- interferes with function of heme-containing proteins
Laboratory
Management
- cyanide antidote pack
- Cyanokit contains hydroxycobalamin*
* cyanide removed as cyanocobalamin[1]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 18, 19 American College of Physicians, Philadelphia 2018, 2022
- ↑ Hamad E, Babu K, Bebarta VS. Case Files of the University of Massachusetts Toxicology Fellowship: Does This Smoke Inhalation Victim Require Treatment with Cyanide Antidote? J Med Toxicol. 2016 Jun;12(2):192-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26831054 Free PMC Article