Lugol's solution (iodine/iodide)
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Introduction
Contraindications
Adverse effects
- not common (> 10%)
- angioedema, fever, headache, urticaria, acne, goiter with hypothyroidism, metallic taste, GI upset, cutaneous & mucosal hemorrhage, eosinophilia, arthralgia, lymph node enlargement, soreness of teeth & gums, rhinitis
Mechanism of action
Iodide limits its own transport & inhibits synthesis of iodotyrosine & iodothyronine. Intracellular iodide concentration appears to be the major determinant. This phenomenon is known as the Wolf-Chaikoff effect (1948). The iodine is reduced to iodide in the intestine before absorbtion.
More general terms
Components
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- ↑ Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990. pg 1014-6
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998