Latrodectus mactans (black widow spider) antivenin

Indications

black widow spider bite

Contraindications

allergy to horse serum

pregnancy-category C

safety in lactation ?

Dosage

• initial intradermal skin test prior to administration
  • 1 mL vial of equine serum for sensitivity testing comes with antivenin
• adults: 1 vial (2.5 mL, 6000 units) IM/IV
• children < 12 years: 2.5 mL in 10-50 mL saline over 15 minutes
• contact regional poison control center if consultation is required

Pharmacokinetics

elimination: liver

Adverse effects

• not common (1-10%)
  • shock
  • edema of the face
  • apprehension
  • peripheral neuritis
  • urticaria
  • muscle weakness
  • anaphylaxis
  • serum sickness

More general terms

• antivenin

Additional terms

• Latrodectus mactans (black widow spider)
• spider bite