CRISPR-associated transposase (CAST, ecoCAST)

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[1]

Introduction

CRISPR without the cuts

Indications

  • can introduce full-length genes at targeted sites in a single ste
    • does noy create DNA double-stranded breaks

More general terms

References

  1. ↑ Dolgin E Powerful CRISPR system inserts whole gene into human DNA. Nature News. May 15, 2025 https://www.nature.com/articles/d41586-025-01518-w
    Witte IP, Lampe GD, Eitzinger S et al Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase. Science. 2025 May 15;388(6748):eadt5199. PMID: https://pubmed.ncbi.nlm.nih.gov/40373119
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