Lactobacillus plantarum
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Epidemiology
- bacteria that colonize the olfactory epithelium of the nose
Adverse effects
- safe to use in treatment
Mechanism of action
- able to bind to a molecule found on the olfactory epithelium
- can be engineered to produce & secrete hormones or other drugs & release them into the olfactory epithelium
- L plantarum unlikely to traverse the blood-brain barrier but can ferry a drug to the point where the drug can do so[1][2]
More general terms
References
- ↑ Jump up to: 1.0 1.1 Ledford H Engineered nose bacteria sneak drugs into the brain. Microbes that reside peaceably in the nasal passageways and on the skin can be harnessed for taking drugs to target cells. Nature News. 2025. Feb 6. https://www.nature.com/articles/d41586-025-00375-x
- ↑ Jump up to: 2.0 2.1 Shen H, Aggarwal N, Cui B et al Engineered commensals for targeted nose-to-brain drug delivery. Cell. 2025 Feb 3:S0092-8674(25)00046-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39914382 https://www.cell.com/cell/fulltext/S0092-8674(25)00046-7