phosphorylated tau217 in dried blood spot

Introduction

capillary p-tau217 from dried blood spot

Indications

• screening for Alzheimer's disease

Procedure

• single finger prick
• single blood drops were applied to a dried plasma spot (DPS) card shipped to a lab (without temperature control or cooling)
• dried plasma spot (DPS) card may be obtained without supervision
  • particularly useful in remote & rural settings

Interpretation

• capillary p-tau217 DPS correlates with plasma ptau-217
• able to discriminate beta-amyloid positive from beta-amyloid negative individuals
• levels provide estimate of cognitive function

Notes

• additional validation in progress
• correlations between dried plasma spot p-tau217 & venous plasma p-tau217 are strong (rs=0.74, 95% CI 0.678-0.791, P<0.001)

More general terms

• microtubule-associated protein tau in body fluid
• point of care test

Additional terms

• phosphorylated tau(Thr)217 in plasma (plasma ptau217)