L1CAM-positive extracellular vesicle alpha-synuclein Ag in serum; L1CAM-positive extracellular vesicle alpha-synuclein Ag in serum
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Indications
- biomarker for alpha-synucleinopathy (Parkinson's disease, Lewy body dementia or multiple system atrophy within 12 years)
Reference interval
- > 27.93 pg/mL associated with alpha-synucleinopathy within 12 years (specificity - 80%)[1]
Methods
- L1CAM positive extracellular vesicles isolated from 250 uL of serum by immunocapture
More general terms
Additional terms
References
- ↑ 1.0 1.1 Yan S, Chang C, Janzen A et al. Neuronally derived extracellular vesicle alpha-synuclein as a serum biomarker for individuals at risk of developing Parkinson disease. JAMA Neurol 2024 Jan 1; 81:59-68. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38048087 PMCID: PMC10696516 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2812433