gepotidacin
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Indications
- treatment of complicated urinary tract infections (UTIs)
* non-inferior to nitrofurantoin for treatment of uncomplicated UTIs
Dosage
Antimicrobial activity
- common uropathogens, including clinically important drug-resistant organisms
Adverse effects
- diarrhea (14%)
Mechanism of action
- inhibits bacterial DNA replication
- inhibition of two type II topoisomerase enzymes
More general terms
References
- ↑ Wagenlehner F, Perry CR, Hooton TM et al Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double- dummy, phase 3, non-inferiority trials. Lancet. 2024 Feb 8:S0140-6736(23)02196-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38342126