Figure: eicosatrienoate cyclooxygenase cascade

Biochemistry

• ETA CO cascade 1
  • enzyme: prostaglandin synthase
  • substrate: eicosatrienoate + O2
  • product: PGG1
• ETA CO cascade 2
  • enzyme: prostaglandin synthase
  • substrate: PGG1 + 2 GSH
  • product: PGH1 + GSSG
• ETA CO cascade 4
  • enzyme: isomerase
  • substrate: PGH1
  • product: PGE1
• ETA CO cascade 5
  • enzyme: isomerase
  • substrate: PGH1
  • product: PGF1-alpha
• ETA CO cascade 9
  • enzyme: isomerase
  • substrate: PGH1
  • product: PGA1