phosphatidylethanol in blood

^[1]^[2]

Indications

phosphatidylethanol in blood cutoffs:^[2]
- light drinking: < 25 ng/mL
- moderate drinking: 25-200 ng/mL
- heavy drinking: > 200 ng/mL
18.5-20 ng/mL can be used in clinical care as a cutoff to detect heavy alcohol consumption in middle-age & older men*^[1]

* sensitivity: 84%, specificity: 73%

↑ ^1.0 ^1.1 Hahn JA, Fatch R, Barnett NP et al Phosphatidylethanol vs Transdermal Alcohol Monitoring for Detecting Alcohol Consumption Among Adults. JAMA Netw Open. 2023;6(9):e2333182. PMID: https://pubmed.ncbi.nlm.nih.gov/37698861 PMCID: PMC10498325 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809197
↑ ^2.0 ^2.1 Tavaglione F et al. Clinical utility of phosphatidylethanol to detect underreported alcohol use and enhance steatotic liver disease subclassification. J Hepatol 2025 Jun 13; PMID: https://pubmed.ncbi.nlm.nih.gov/40517819 https://www.journal-of-hepatology.eu/article/S0168-8278(25)02269-X/abstract
Torp N et al. Phosphatidylethanol and self-reported alcohol intake to subclassify in individuals at risk of steatotic liver disease: An analysis of data from a prospective cohort study. Lancet Gastroenterol Hepatol 2025 Sep 10; [e-pub]. PMID: https://pubmed.ncbi.nlm.nih.gov/40945520 https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00187-6/abstract