Figure: heme synthesis

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Epidemiology

  • heme is produced in virtually all mammalian tissues

Pathology

* porphyrins are intermediates in heme synthesis

Biochemistry

biosynthetic pathway

alternative pathway from porphobilinogen

References

  1. Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 1009