aminolevulinic acid [ALA] synthetase

Introduction

1st & rate limiting enzyme in heme biosynthetic pathway; catalyzes condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid

More general terms

• acyltransferase
• oligomerizing protein
• allosteric enzyme

More specific terms

• ALA synthetase-1 (nonspecific 5-aminolevulinate synthetase mitochondrial, ALAS-H, ALAS1, ALAS3, ALASH, OK/SW-cl121)
• ALA synthetase-2 (ALAS2, erythroid-specific 5-aminolevulinate synthetase, erythrocytic aminolevulinate synthetase)

Additional terms

• heme synthesis