Figure: lesions removed by DNA base excision repair

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Introduction

Lesions removed by base excision repair.

DNA base lesions are excised by DNA glycosylases.

Uracil & hypoxanthine are deamination products formed by hydrolysis

3-methyladenine, 7-methylguanine & 2-methylcytosine are products of methylation caused by methylating agents such as the endogenous S-adenosylmethionine (SAM) or the chemotherapeutic agent N-methyl-N- nitrosourea.

The remainder are lesions caused by active oxygen species.

References

  1. Seeberg E et al The base excision repair pathway. TIBS 20:391 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533150