polygenic risk score
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Introduction
Presumptively genetic profiling for cardiometabolic diseases
- coronary artery disease
- hypercholesterolemia
- type 2 diabetes
- atrial fibrillation
- venous thromboembolic disease & response to drug therapy[1]
Disadvantages
- inferior to coronary artery calcium score[2]
More general terms
References
- ↑ 1.0 1.1 O'Sullivan JW, Raghavan S, Marquez-Luna C et al Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2022 Aug 23;146(8):e93-e118. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35862132 PMCID: PMC9847481 (available on 2023-08-23) https://jamanetwork.com/journals/jama/fullarticle/2805138
- ↑ 2.0 2.1 Khan SS et al. Coronary artery calcium score and polygenic risk score for the prediction of coronary heart disease events. JAMA 2023 May 23; 329:1768. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37219552 PMCID: PMC10208141 (available on 2023-11-23) https://jamanetwork.com/journals/jama/fullarticle/2805138