urolithin A
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Introduction
Bioactive metabolite of ellagitannins.
Clinical significance
- does not improve 6 minute walk distance[3]
* some suggestion that long-term supplementation may have some benefit for muscle endurance & plasma biomarkers[3]
Comparative biology
- stimulates mitophagy & improves muscle function in older animals
- induces mitochondrial gene expression in older humans
More general terms
References
- ↑ D'Amico D, Andreux PA, Valdes P, Singh A, Rinsch C, Auwerx J. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends Mol Med. 2021 Jul;27(7):687-699. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34030963 Review.
- ↑ Andreux PA, Blanco-Bose W, Ryu D et al The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019 Jun;1(6):595-603. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32694802
- ↑ 3.0 3.1 3.2 Liu S, D'Amico D, Shankland E et al Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jan 4;5(1):e2144279. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35050355 PMCID: PMC8777576 Free PMC article