antibody dependent enhancement (ADE)
Jump to navigation
Jump to search
Introduction
Mechanism by which pathogenesis of viral infections is enhanced by sub-neutralizing or cross-reactive non-neutralizing antiviral antibodies. These virus-specific antibodies enhance entry & replication of virus in monocytes/macrophages or granulocytic cells through interaction with Fc &/or complement receptors[2].
The most well-known example is with dengue virus where a subsequent infection with a different serotype can cause more severe & possibly lethal disease such as dengue hemorrhagic fever or dengue shock syndrome[3].
References
- ↑ Cancel Tirado SM , Yoon KJ Antibody-dependent enhancement of virus infection and disease. Viral Immunol 2003;16(1):69-86. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12725690
- ↑ 2.0 2.1 Bournazos S, Gupta A, Ravetch JV. The role of IgG Fc receptors in antibody-dependent enhancement. Nat Rev Immunol. 2020 Oct;20(10):633-643. Epub 2020 Aug 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32782358
- ↑ 3.0 3.1 Ulrich H, Pillat MM, Tarnok A Dengue Fever, COVID-19 (SARS-CoC2), and Antibody-Dependent Enhancement (ADE): A Perspective Cytometry Part A, J Quantitative Cell Science: 97(7):662-667 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32506725