small cysteine & glycine repeat-containing protein 9; keratin-associated protein 28p1 (SCYGR9, KRTAP28p1)

Function

• in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins, essential for the formation of a rigid & resistant hair shaft through extensive disulfide bond cross-linking with abundant Cys of <A128357>hair keratins</A128357>
• matrix proteins include the high-sulfur & high-glycine-tyrosine keratins

Structure

belongs to the KRTAP type 28 family

Polymorphism

• the most frequent variant has a stop codon instead of Cys-15, giving rise to a truncated protein
• the variant Cys-15 is rare, except in some populations from Africa & non-Finnish Europa

Notes

• humans have a similar number of genes as other primates despite the relative hairlessness of humans

More general terms

• ketatin-associated protein (KRTAP)

Database

• UniProt: http://www.uniprot.org/uniprot/P0DSO2.html