transdermal nitrate

Introduction

Variety of forms. (also see nitroglycerin)

Dosage

Ointment: 2% (Nitropaste): Tradenames Nitro-bid, Nitrol.

• 0.5-5 inches every 4-8 hours. Remove every 8/day (to avoid tolerance) [15 mg/inch]. (30 g, 60 g)

Transdermal:

• 1 patch QD. Deponit: 0.2, 0.4 mg/hr. Minitran: 0.1, 0.2, 0.4, 0.6 mg/hr. Nitro-Dur: 0.1, 0.2, 0.3, 0.4, 0.6, 0.8 mg/hr. Nitrodisc: 0.2, 0.3, 0.4 mg/hr. Transderm-Nitro: 0.1, 0.2, 0.4,0.6, 0.8 mg/hr.

Conversion:

• ointment < 1 inch
• patch 0.4 mg/hr
• dinitrate 20 mg TID

Major advantage is that medication can be removed easily.

More general terms

• transdermal therapeutic system (TTS, transdermal patch)