flavocoxid (Limbrel)

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Introduction

Not a prescription medication

Not an over-the-counter medication

Not a dietary supplement

Not a COX-2 inhibitor

FDA recommends stop taking, contact health provider[4]

Indications

Dosage

  • Limbrel250, Limbrel500

Mechanism of action

  • extract containing plant flavanoids
  • no proof of effectiveness

Complications

Notes

cost $90/month

More general terms

Components

References

  1. Prescriber's Letter 12(5): 2005 Medical Food: Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210515&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. 2.0 2.1 2.2 Chalasani N et al Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis: A Case Series Ann Intern Med. 19 June 2012;156(12):857-860 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711078 <Internet> http://annals.org/article.aspx?articleid=1183011
    Reichenbach S and Juni P Medical Food and Food Supplements: Not Always as Safe as Generally Assumed Ann Intern Med. 19 June 2012;156(12):894-895 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711083 <Internet> http://annals.org/article.aspx?articleid=1183012
  3. Prescriber's Letter 19(9): 2012 Liver Toxicity and Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280907&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 4.2 4.3 4.4 FDA Safety Watch. Nov 21, 2017 Limbrel Capsules by Primus Pharmaceuticals: FDA Advisory - Linked to Potentially Life-Threatening Health Problems. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586111.htm
  5. Limbrel Product Information http://www.limbrel.com/downloads/limbrel_pi.pdf