flavocoxid (Limbrel)
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Introduction
Not a prescription medication
Not an over-the-counter medication
Not a dietary supplement
Not a COX-2 inhibitor
FDA recommends stop taking, contact health provider[4]
Indications
- marketed to treat metabolic processes associated with osteoarthritis
Dosage
- Limbrel250, Limbrel500
Mechanism of action
- extract containing plant flavanoids
- no proof of effectiveness
Complications
- reversible hepatotoxicity[2][4]; 4 cases (0.01%)
- hypersensitivity pneumonitis[4]
Notes
cost $90/month
More general terms
Components
References
- ↑ Prescriber's Letter 12(5): 2005 Medical Food: Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210515&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 2.0 2.1 2.2 Chalasani N et al Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis: A Case Series Ann Intern Med. 19 June 2012;156(12):857-860 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711078 <Internet> http://annals.org/article.aspx?articleid=1183011
Reichenbach S and Juni P Medical Food and Food Supplements: Not Always as Safe as Generally Assumed Ann Intern Med. 19 June 2012;156(12):894-895 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711083 <Internet> http://annals.org/article.aspx?articleid=1183012 - ↑ Prescriber's Letter 19(9): 2012 Liver Toxicity and Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280907&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 4.0 4.1 4.2 4.3 4.4 FDA Safety Watch. Nov 21, 2017 Limbrel Capsules by Primus Pharmaceuticals: FDA Advisory - Linked to Potentially Life-Threatening Health Problems. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586111.htm
- ↑ Limbrel Product Information http://www.limbrel.com/downloads/limbrel_pi.pdf