flavocoxid (Limbrel)

^[1]^[2]^[3]^[4]^[5]

Introduction

Not a prescription medication

Not an over-the-counter medication

FDA recommends stop taking, contact health provider^[4]

extract containing plant flavanoids
- baicalin (from Scutellaria baicalensis) & catechin (from Acacia catechu)
- also contains zinc
no proof of effectiveness

reversible hepatotoxicity^[2]^[4]; 4 cases (0.01%)
- all cases in women^[2]
- incidence may be higher than that previously reported^[4]
hypersensitivity pneumonitis^[4]

cost $90/month

↑ Prescriber's Letter 12(5): 2005 Medical Food: Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210515&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^2.0 ^2.1 ^2.2 Chalasani N et al Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis: A Case Series Ann Intern Med. 19 June 2012;156(12):857-860 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711078 <Internet> http://annals.org/article.aspx?articleid=1183011
Reichenbach S and Juni P Medical Food and Food Supplements: Not Always as Safe as Generally Assumed Ann Intern Med. 19 June 2012;156(12):894-895 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711083 <Internet> http://annals.org/article.aspx?articleid=1183012
↑ Prescriber's Letter 19(9): 2012 Liver Toxicity and Limbrel Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280907&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 FDA Safety Watch. Nov 21, 2017 Limbrel Capsules by Primus Pharmaceuticals: FDA Advisory - Linked to Potentially Life-Threatening Health Problems. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586111.htm
↑ Limbrel Product Information http://www.limbrel.com/downloads/limbrel_pi.pdf