Landolfi' sign

Etiology

• may be seen in patients with severe aortic regurgitation

Pathology

• manifestation of wide pulse pressure & large stroke volume in the iridial vessels, which causes systolic constriction & diastolic dilation of the pupils

Clinical manifestations

• dilation & constriction of the pupils, synchronized with patient's heartbeat
• murmur of aortic regurgitation is crescendo-decrescendo

* image

Radiology

• transthoracic echocardiography reveals severe aortic regurgitation
  • dilatation of the ascending aorta may also be observed