immunoglobulin heavy variable 1-3 (IGHV1-3)
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Function
- V region variable domain of immunoglobulin heavy chains
- variable domains are assembled by V-(D)-J rearrangement & can then be subjected to somatic hypermutations which, after exposure to antigen & selection, allow affinity maturation for a particular antigen
Structure
contains 1 Ig-like (immunoglobulin-like) domain
Compartment
Polymorphism
- several alleles
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/A0A0C4DH29.html
- ↑ UniProt PubMed refs
PMID: https://www.ncbi.nlm.nih.gov/pubmed/22158414
PMID: https://www.ncbi.nlm.nih.gov/pubmed/20176268
PMID: https://www.ncbi.nlm.nih.gov/pubmed/176268 - ↑ IMGT/GENE-DB http://www.imgt.org/IMGT_GENE-DB/GENelect?query=2+IGHV1-3&species=homo+sapiens