DNA vaccine
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Advantages
- can be produced relatively rapidly & inexpensively
- do not require refrigeration
- can induce vigorous humoral & cellular immune responses
Mechanism of action
- DNA vaccines involve injecting DNA that encodes immunogenic antigens into tissue (usually muscle)
- cells take up the vaccine, begin to produce immunogenic protein, & humoral & cellular immune responses against the antigens follow
Comparative biology
- single dose of DNA vaccine against Zika virus provides protection in rhesus macaques[1]
More general terms
References
- ↑ Jump up to: 1.0 1.1 Komaroff AL DNA Vaccine Against Zika Virus Yields Promising Results in Primates NEJM Journal Watch. Jan 3, 2017 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
Dowd KA, Ko SY, Morabito KM et al. Rapid development of a DNA vaccine for Zika virus. Science 2016 Oct 14; 354:237 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27708058