telomere disease

^[1]^[2]

Etiology

more rapid shortening of telomeres with cell division
aplastic anemia
pulmonary fibrosis
liver cirrhosis
leukoplakia
reduced telomer length associate with increased overall motality (RR=1.08), cardiovascular mortality (RR=1.09), respiratory mortality (RR=1.40), digestive system mortality (RR=1.26), musculoskeletal mortality (RR=1.51), & COVID-19 mortality (RR=1.15) mortality, but not cancer-related mortality^[2]

↑ ^1.0 ^1.1 Townsley DM et al. Danazol treatment for telomere diseases. N Engl J Med 2016 May 19; 374:1922 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27192671
Lansdorp PM. Telomeres on steroids - turning back the mitotic clock? N Engl J Med 2016 May 19; 374:1978 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27192677
↑ ^2.0 ^2.1 Schneider CV, Schneider KM, Teumer A et al Association of Telomere Length With Risk of Disease and Mortality. JAMA Intern Med. Published online January 18, 2022 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35040871 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788295