proximal tubulopathy

Etiology

• monoclonal gammopathy of uncertain significance (MGUS)
• multiple myeloma

Clinical manifestations

• +/- Fanconi syndrome

Laboratory

• basic metabolic panel
  • normal anion gap
    • hyperchloremic renal tubular acidosis
• serum phosphorus: hypophosphatemia
• urinalysis & urine chemistries
  • urine glucose: glucosuria
  • urine amino acids: aminoaciduria
• serum uric acid: hypouricemia
• renal biopsy

More general terms

• renal tubular disease