centromere antibody in serum
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Etiology
- present in 70 to >90% of patients with CREST syndrome[2]
- sensitivity for CREST syndrome 10-30%[2]
- overall prevalence in systemic sclerosis ~30%[2]
- present in 1% of patients with diffuse scleroderma
Principle
- originally detected by immunofluorescence microscopy with the antigen localized to the region of condensing metaphase chromosomes
- routinely detected via immunoblots
- centromere antigens consist of three proteins, of 16, 80 & 120 kD MW.
Clinical significance
- no correlation between antibody titers & disease activity
- CREST syndrome patients with anti-centromere Ab are more likely to develop pulmonary hypertension[2]
Methods
test is performed using cell lines such as Hep2
Specimen
More general terms
More specific terms
- centromere protein A antibody in serum
- centromere protein B antibody in serum
- centromere protein F antibody in serum
Additional terms
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1019
- ↑ 2.0 2.1 2.2 2.3 2.4 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995