endomysial antibody in serum

Introduction

see tissue transglutaminase antibody in serum

Indications

• positive values present in 70-80% of patients with:
  • celiac disease*
  • dermatitis herpetiformis

* rule out celiac disease prior to diagnosis of irritable bowel syndrome

Reference interval

negative

Clinical significance

• IgA antibody has sensitivity, specificity & positive predictive value of 95% for celiac sprue

Methods

monkey esophagus is used as tissue substrate

Specimen

serum; store at -20 degrees C

More general terms

• serology

More specific terms

• endomysial antibody IgA in serum
• endomysial antibody IgG in serum

Additional terms

• anti-endomysial antibody
• celiac sprue (gluten-sensitive enteropathy)
• endomysium