multitarget stool DNA; mt-sDNA, (Cologuard)

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Introduction

FDA-approved August 2014

Indications

* Cologuard Plus is substantially more sensitive, but slightly less specific, than fecal immunochemical test

Procedure

Interpretation

* lower value for prior negative colonoscopy

* more sensitive but less specific than fecal immunochemical test (FIT)[4][5]

More general terms

References

  1. Young K Physician's First Watch, March 27, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  2. Medscape Oncology> August 11, 2014 FDA Approves Cologuard for Colorectal Cancer Screening. http://www.medscape.com/viewarticle/829757
  3. 3.0 3.1 Eckmann JD, Ebner DW. Bering J et al. Multitarget stool DNA screening in clinical practice: High positive predictive value for colorectal neoplasia regardless of exposure to previous colonoscopy. Am J Gastroenterol 2020 Apr; 115:608 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32068535 https://journals.lww.com/ajg/FullText/2020/04000/Multitarget_Stool_DNA_Screening_in_Clinical.20.aspx
  4. 4.0 4.1 4.2 Voss JK et al. Multitarget stool DNA testing has high positive predictive value for colorectal neoplasia on the second round of testing. Clin Gastroenterol Hepatol 2023 Aug; 21:2399. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36621751 PMCID: PMC10323033 (available on 2024-08-01) https://www.cghjournal.org/article/S1542-3565(23)00004-6/fulltext
  5. 5.0 5.1 5.2 5.3 Imperiale TF, Porter K, Zella J et al. Next-generation multitarget stool DNA test for colorectal cancer screening. N Engl J Med 2024 Mar 14; 390:984-993. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38477986 https://www.nejm.org/doi/10.1056/NEJMoa2310336
    Kisiel JB, Eckmann JD, Limburg PJ. Multitarget Stool DNA for Average Risk Colorectal Cancer Screening: Major Achievements and Future Directions. Gastrointest Endosc Clin N Am. 2020 Jul;30(3):553-568. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32439088 PMCID: PMC10964930 Free PMC article. Review.