statin intolerance
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Classification
- partial statin intolerance is the inability to tolerate a statin dose required to achieve a therapeutic effect, but able to tolerate lower doses
- complete statin intolerance is the inability to tolerate any statin dose
Management
- bempedoic acid/ezetimibe may be useful in statin intolerant patients
- treatment with bempedoic acid reduces risk of major cardiovascular events[3]
- PCSK9 inhibitor may be useful in statin intolerant patients
More general terms
References
- ↑ Windle ML Rapid Rx Quiz: Statin Intolerance and Related Concerns Medscape. September 01, 2022 https://reference.medscape.com/viewarticle/979515
- ↑ Ballantyne CM, Banach M, Mancini GBJ et al Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study. Atherosclerosis. 2018 Oct;277:195-203. Epub 2018 Jun 12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29910030 Free Article
- ↑ 3.0 3.1 Nissen SE, Lincoff AM, Brennan D et al Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med 2023. March 4 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36876740 https://www.nejm.org/doi/10.1056/NEJMoa2215024