immunoglobulin heavy variable 1-8 (IGHV1-8)

Function

• V region variable domain of immunoglobulin heavy chains
• variable domains are assembled by V-(D)-J rearrangement & can then be subjected to somatic hypermutations which, after exposure to antigen & selection, allow affinity maturation for a particular antigen

Structure

contains 1 Ig-like (immunoglobulin-like) domain

Compartment

secreted

Polymorphism

• several alleles

More general terms

• Ig heavy chain variable region (IgVH)

Database

• UniProt: http://www.uniprot.org/uniprot/P0DP01.html