glucosepane
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Structure
- lysine-arginine protein cross-linking product & advanced glycation end product (AGE) derived from D-glucose
Pathology
- irreversible, covalent cross-link product found to make intermolecular & intramolecular cross-links in collagen of the extracellular matrix & crystallin of the eyes
- present in human tissues at levels 10-1000 times higher than any other cross-linking AGE
More general terms
- advanced glycation endproduct (AGE) pigment
- heterocyclic compound, 2 rings
- carboxylate
- amine
- alcohol
References
- ↑ Wikipedia: Glucosepane https://en.wikipedia.org/wiki/Glucosepane
- ↑ sens research foundation GlycoSENS: Breaking extracellular crosslinks http://www.sens.org/research/introduction-to-sens-research/extracellular-crosslinks
- ↑ sens research foundation Yale University: Glucosepane Crosslinks and Routes to Cleavage. http://www.sens.org/research/extramural/scaling-up-glucosepane-research