cocaine-levamisole-induced cutaneous vasculitis
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Etiology
- cocaine abuse, cocaine cut with veterinary antihelmintic levamisole
Pathology
- inhaled levamisole in cocaine is associated with cutaneous vasculitis
Clinical manifestations
- palpable purpura or bullae with ear involvement
- oral mucosal ulceration
- arthralgias
Laboratory
- complete blood count (CBC)
- positive cANCA in serum in high titers
- variable myeloperoxidase Ab in serum (p-ANCA)
Management
- NSAIDS 1st-line for arthralgias
- colchicine & systemic glucocorticoid to manage severe & persistent skin lesions
More general terms
References
- ↑ Poon SH, Baliog CR Jr, Sams RN et al Syndrome of cocaine-levamisole-induced cutaneous vasculitis and immune-mediated leukopenia. Semin Arthritis Rheum. 2011 Dec;41(3):434-44. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21868067