ivacaftor/lumacaftor (Orkambi)
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Indications
- treatment of cystic fibrosis with 2 sopies of the CFTR mutation F508del (phenylalanine 508 mutation)*
* most common mutation in cystic fibrosis
Dosage
- lumacaftor 200 mg/ivacaftor 125 mg
- 2 pills every 12 hours
Adverse effects
Mechanism of action
- CFTR potentiator
More general terms
Components
References
- ↑ FDA News Release. July 2, 2015 FDA approves new treatment for cystic fibrosis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm453565.htm