d-serine
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Function
- serine racemase forms D-serine from L-serine
- D-serine is a co-agonist with glutamate at NMDA receptors
- main co-agonist of NMDA receptors in frontal cortex[1]
Pathology
- D-serine levels are elevated in the hippocampus & parietal cortex of subjects with neuropathologically confirmed Alzheimer's disease[1]
Laboratory
- D-serine in CSF in connection with CSF Abeta42 & CSF tau is a marker for Alzheimer's disease[1]
Notes
- native amino acids used for protein synthesis are L-amino acids
More general terms
Additional terms
References
- ↑ 1.0 1.1 1.2 1.3 Madeira C et al. D-serine levels in Alzheimer's disease: Implications for novel biomarker development. Transl Psychiatry 2015 May 26; 5:e561 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25942042 <Internet> http://www.nature.com/tp/journal/v5/n5/full/tp201552a.htm