SLIT-ROBO Rho GTPase-activating protein 2B; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2 (SRGAP2B, SRGAP2P2)

Function

• may regulate cell migration & differentiation through interaction with & inhibition of SRGAP2
• homodimer with SRGAP2 inhibits SRGAP2 function (putative)

Structure

• contains 1 FCH domain

Genetics

• one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specific segmental gene duplications
• appearance of SRGAP2B in the human genome is estimated to 3,4 million years
• 2 larger duplications later copied SRGAP2B to chromosome 1p12 (SRGAP2C) & to proximal 1q21.1 (SRGAP2D)
• SRGAP2B was identified in some individuals but it is not clear if it produces a functional protein

More general terms

• rho GTPase-activating protein (rho-GAP)
• evolutionary divergent human protein

Database

• OMIM: https://mirror.omim.org/entry/614703
• UniProt: http://www.uniprot.org/uniprot/P0DMP2.html