sulfotransferase 1A4; ST1A4; aryl sulfotransferase 1A3/1A4; sulfotransferase 1A3/1A4 (SULT1A4)

Function

• sulfotransferase
• utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfate conjugation of phenolic monoamines (neurotransmitters, i.e. dopamine, norepinephrine & serotonin) & phenolic & catechol drugs

3'-phosphoadenylyl sulfate + a phenol
           <-->
adenosine 3',5'-bisphosphate + an aryl sulfate

Structure

• the N-terminus is blocked
• homodimer
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm

Expression

• expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta & leukocytes

Genetics

• found in a segmental duplication on p arm of chromosome 16 giving rise to 2 identical copies of this gene sharing exons with SLX1A & SLX1B
• the ORFs of SULT1A3 & SULT1A4 differ with only a single nucleotide change that does not alter the encoded amino acid
• it is not possible to determine whether any individual polymorphism is present within SULT1A3 or SULT1A4

More general terms

• sulfotransferase

Database

• OMIM: https://mirror.omim.org/entry/615819
• UniProt: http://www.uniprot.org/uniprot/P0DMN0.html