monoamine sulfotransferase; sulfotransferase 1A3/1A4; monoamine-sulfating phenol sulfotransferase; aryl sulfotransferase 1A3/1A4; sulfotransferase, monoamine-preferring; M-PST; thermolabile phenol sulfotransferase; TL-PST; placental estrogen sulfotransferase; catecholamine-sulfating phenol sulfotransferase; HAST3 (SULT1A3, STM, SULT1A4)

Function

• sulfotransferase
• utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfate conjugation of phenolic monoamines (neurotransmitters, i.e. dopamine, norepinephrine & serotonin) & phenolic & catechol drugs

3'-phosphoadenylyl sulfate + a phenol
           <-->
adenosine 3',5'-bisphosphate + an aryl sulfate

Structure

• homodimer
• N-terminus is blocked
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta & leukocytes

Genetics

• found in a segmental duplication on p arm of chromosome 16 giving rise to 2 identical copies of this gene sharing exons with SLX1A & SLX1B
• the ORFs of SULT1A3 & SULT1A4 differ with only a single nucleotide change that does not alter the encoded amino acid
• it is not possible to determine whether any individual polymorphism is present within SULT1A3 or SULT1A4

More general terms

• sulfotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=445329
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6818
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:445329
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6818
• OMIM: https://mirror.omim.org/entry/600641
• UniProt: http://www.uniprot.org/uniprot/P0DMM9.html