aquaporin-7; AQP-7; aquaporin adipose; AQPap (AQP7, AQP7L, AQP9)
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Function
Structure
- aquaporins contain 2 tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
- belongs to the MIP/aquaporin (TC 1.A.8) family
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
expressed predominantly in adipose tissue
Polymorphism
- genetic variations in AQP7 are responsible for changes in glycerol release during exercise & define the glycerol quantitative trait locus (GLYCQTL)
Evolution
- segmental duplication of chromosome 9 involving AQP7 is one of the few features distinguishing the human genome from the chimpanzee genome.[1][2] (see evolutionary divergent human protein)
More general terms
References
- ↑ 1.0 1.1 OMIM https://mirror.omim.org/entry/602974
- ↑ 2.0 2.1 Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour- Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15252450
- ↑ UniProt http://www.uniprot.org/uniprot/O14520.html