Meiosis-specific kinetochore protein (MEIKIN)

Function

• key regulator of kinetochore function during meiosis I
• required both for mono-orientation of kinetochores on sister chromosomes & protection of centromeric cohesin from separase-mediated cleavage
• acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction & are thus captured & pulled by spindle fibers from the same pole
• also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway
• acts in collaboration with PLK1: required for PLK1 enrichemnt to kinetochores
• not required during meiosis II or mitosis
• interacts with CENPC
• interacts with PLK1
• required for recruitment of PLK1 at kinetochores

Compartment

• chromosome, centromere, kinetochore
• localizes at kinetochores in meiosis I but undetectable in meiosis II

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728637
• UniProt: http://www.uniprot.org/uniprot/A0A087WXM9.html