HLA-B*1502 allele
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Indications
- epilepsy, neuropathic pain
- assessment of risk for Stevens-Johnson syndrome & toxic epidermal necrolysis
- carbamazepine, lamotrigine or phenytoin therapy in high-risk populations*
* Han Chinese at highest risk
* persons from Vietnam, Cambodia, the Reunion Islands, Thailand, India (specifically Hindus), Malaysia, & Hong Kong
Clinical significance
- carbamazepine, lamotrigine & phenytoin induced Stevens-Johnson syndrome & toxic epidermal necrolysis is associated with HLA-B*1502 allele in high-risk populations
More general terms
Additional terms
References
- ↑ Mayo Clinic Laboratories: HLA-B 1502 Genotype, Carbamazepine Hypersensitivity http://www.mayomedicallaboratories.com/test-catalog/Overview/89347
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
- ↑ Hung SI, Chung WH, Liu ZS et al Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20235791