metallothionein 1H-like protein 1 (MT1HL1)

Function

• metallothioneins have a high content of Cys that bind various heavy metals
• transcriptionally regulated by both heavy metals & glucocorticoids (putative)

Structure

• class I metallothioneins contain 2 metal-binding domains:
  • four divalent ions are chelated within cluster A of the alpha domain & are coordinated via cysteinyl thiolate bridges to 11 Cys ligands
  • Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 Cys
• belongs to the metallothionein superfamily, type 1 family

Notes

• encoded by an expressed retrotransposed copy of the MT1H locus

More general terms

• uncharacterized protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=645745
• UniProt: http://www.uniprot.org/uniprot/P0DM35.html