PER977
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Indications
- potentially useful for treating hemorrage associated with use of direct oral anticoagulants (factor Xa inhibitors)[1]
* fresh-frozen plasma & prothrombin complex may also be useful in this context
Adverse effects
- minimal[1]
Mechanism of action
- binds to all of the new oral anticoagulants & heparin & inhibits their anticoagulant activity[1]
More general terms
References
- ↑ 1.0 1.1 1.2 1.3 Ansell JE et al Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban. N Engl J Med. November 5, 2014. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25371966 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMc1411800