laryngeal carcinoma
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Etiology
Pathology
- acid reflux may cause cancers by inducing chronic inflammation
- most are squamous cell carcinomas
Clinical manifestations
Laboratory
Diagnostic procedures
Radiology
Complications
- injury to the vocal cords
- 95% are squamous cell carcinomas
- 20% risk of 2nd cancer within 2 years
Management
- stages 1 or 2
- radiation with intent to cure
- stages 3 & 4 without distant metastases
- combination of radiation, chemotherapy
- metastatic disease or recurrence
- chemotherapy is palliative, but does not prolong survival
- surgical resection should be avoided if vocal cords may be compromised
- radiation therapy for local mass effects
More general terms
Additional terms
References
- ↑ Vaezi MF et al. Laryngeal cancer and gastroesophageal reflux disease: A case-control study. Am J Med 2006 Sep; 119:768-76. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16945612
- ↑ Langevin SM et al Gastric Reflux Is an Independent Risk Factor for Laryngopharyngeal Carcinoma. Cancer, Epidemiology, Biomarkers & Prevention. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23703970 <Internet> http://cebp.aacrjournals.org/content/early/2013/05/21/1055-9965.EPI-13-0183
- ↑ Chu EA, Kim YJ Laryngeal cancer: diagnosis and preoperative work-up. Otolaryngol Clin North Am. 2008 Aug;41(4):673-95, PMID: https://www.ncbi.nlm.nih.gov/pubmed/18570953
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
- ↑ Forastiere AA, Goepfert H, Maor M et al Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003 Nov 27;349(22):2091-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14645636
- ↑ Chera BS, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM. T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):461-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20153124