mipomersen (Kynamro)

Indications

• homozygous familial hypercholesterolemia, as an adjunct to other anti-hyperlipidemic agent & diet

Adverse effects

• injection-site reactions
• flu-like symptoms
• nausea
• headache
• elevated serum transaminases
• boxed warning for increased risk hepatotoxicity

• drug adverse effects of anti-hyperlipidemic agents

Mechanism of action

• blocks transcription of proteins by binding to mRNA
• lowers LDL cholesterol levels ~25%
• lowers serum apolipoprotein B, total cholesterol, & non-HDL cholesterol

More general terms

• anti-hyperlipidemic agent