alternative prion protein; AltPrP ()

Compartment

• mitochondrial outer membrane
• single-pass membrane protein

Expression

• detected in brain homogenate, primary neurons, & peripheral blood mononuclear cells (at protein level)
• up-regulated by endoplasmic reticulum stress & proteasomal inhibition

Genetics

• produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame

Comparative biology

• in mouse & hamster, the alternative initiation AUG codon is absent & is replaced by a GUG codon

Notes

• the alternative prion protein/AltPrP & PRNP (ACP04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP

More general terms

• mitochondrial protein
• membrane protein

Additional terms

• CD230 or major prion protein (PrP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5621
• UniProt: http://www.uniprot.org/uniprot/F7VJQ1.html