atypical fibroxanthoma

Etiology

• radiation injury
  • sun damage
  • radiation therapy

Epidemiology

• older patients

Pathology

• neoplasm has anaplastic appearance
• highly atypical & pleomorphic cellular appearance
• may be a superficial form of malignant fibrous histiocytoma with a much better prognosis
• may be primary squamous cell carcinoma that fails to express keratin

Clinical manifestations

• head & neck
• tumors arise rapidly (over a few weeks or months) in skin in which other skin cancers have been found & treated

Management

• good response to excision

More general terms

• fibroma
• xanthoma