cytosolic 5'-nucleotidase 3A; cytosolic 5'-nucleotidase 3; cytosolic 5'-nucleotidase III; pyrimidine 5'-nucleotidase 1; P5'N-1; P5N-1; PN-I; uridine 5'-monophosphate hydrolase 1; p36 (NT5C3A, NT5C3, P5N1, UMPH1, HSPC233)

Function

• can act both as nucleotidase & as phosphotransferase

Kinetic parameters:

• KM=66 uM for CMP

Structure

• monomer
• belongs to the pyrimidine 5'-nucleotidase family

Compartment

• cytoplasm (putative)
• isoform 2: endoplasmic reticulum

Alternative splicing

• named isoforms=4

Expression

• isoform 1 & 2 are expressed in reticulocytes & lymphocytes
• isoform 3 is expressed only in reticulocytes
• isoform 2 is induced by interferon alpha in Raji cells in association with lupus inclusions

Pathology

• defects in NT5C3 are the cause of pyrimidine 5' nucleotidase deficiency hemolytic anemia

More general terms

• 5'nucleotidase (5'-ribonucleotide phosphohydrolase)

Additional terms

• pyrimidine 5' nucleotidase deficiency hemolytic anemia; P5N deficiency

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51251
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51251
• OMIM: https://mirror.omim.org/entry/266120
• OMIM: https://mirror.omim.org/entry/606224
• UniProt: http://www.uniprot.org/uniprot/Q9H0P0.html