diphthine-ammonia ligase; ATP-binding domain-containing protein 4; diphthamide synthase; diphthamide synthetase; protein DPH6 homolog (DPH6, ATPBD4)

Function

• amidase
• catalyzes the last step of diphthamide biosynthesis* using ammonium & ATP

* diphthamide biosynthesis converts an L-histidine residue in the translation elongation factor (EEF2) to diphthamide

ATP + diphthine-[[[A18155|translation elongation factor]] 2] + NH3 = AMP + diphosphate + diphthamide-[[[A18155|translation elongation factor]] 2]

Structure

belongs to the diphthine-ammonia ligase family

Alternative splicing

named isoforms=2

More general terms

• amidohydrolase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89978
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89978
• UniProt: http://www.uniprot.org/uniprot/Q7L8W6.html